WASHINGTON (AP) — Secretary of State Antony Blinken will travel to China this coming week as Washington and Beijing try to keep ties on an even keel despite major differences on issues from the path to peace in the Middle East to the supply of synthetic opioids that have heightened fears over global stability.

The rivals are at odds on numerous fronts, including Russia’s war in Ukraine, Taiwan and the South China Sea, North Korea, Hong Kong, human rights and the detention of American citizens. The United States and China also are battling over trade and commerce issues, with President Joe Biden announcing new tariffs on imports of Chinese steel this past week.

The State Department said Saturday that Blinken, on his second visit to China in less than a year, will travel to Shanghai and Beijing starting Wednesday for three days of meetings with senior Chinese officials, including Foreign Minister Wang Yi. Talks between Blinken and Chinese President Xi Jinping are expected, although neither side will confirm such a meeting is happening until shortly before it takes place.

The trip follows a phone call this month between Biden and Xi in which they pledged to keep high-level contacts open, something they had agreed to last year at a face-to-face summit in California. Since that call, Treasury Secretary Janet Yellen has visited China and Defense Secretary Lloyd Austin has spoken by phone with his Chinese counterpart. Meetings at lower levels also have taken place.

Despite those encounters, relations are rocky. The U.S. has recently become more vocal in its calls for China to stop supporting Russia’s military-industrial sector, which Washington says has allowed Moscow to boost weapons production to support the war against Ukraine.

“We see China sharing machine tools, semiconductors, other dual-use items that have helped Russia rebuild the defense industrial base that sanctions and export controls had done so much to degrade,” Blinken said Friday. “Now, if China purports on the one hand to want good relations with Europe and other countries, it can’t on the other hand be fueling what is the biggest threat to European security since the end of the Cold War.”

Blinken also has pushed for China to take a more active stance in pressing Iran not to escalate tensions in the Middle East. He has spoken to his Chinese counterpart several times since the Israel-Hamas war began six months ago as he has sought China's help in getting Iran to restrain proxy groups it has supported, armed and funded in the region.

That topic has taken on new urgency since direct back-and-forth attacks by Iran and Israel on each other’s soil in the past week.

Also high on the agenda for Blinken will be Taiwan and the South China Sea.

The U.S. has strongly condemned Chinese military exercises threatening Taiwan, which Beijing regards as a renegade province and vowed to reunify with the mainland by force if necessary. Successive U.S. administrations have steadily ramped up military support and sales for Taipei, much to the anger of Chinese officials.

In the South China Sea, the U.S. and others have become increasingly concerned by provocative Chinese actions in and around disputed areas. In particular, the U.S. has voiced objections to what it says are Chinese attempts to thwart legitimate activities by others in the waterway, notably the Philippines and Vietnam.

That was a major topic of concern earlier this month when Biden held a three-way summit with the prime minister of Japan and the president of the Philippines.